Through a grant from the Institute of Museum and Library Services, OCLC and the Public Library Association have conducted research into how public libraries are supporting their communities through the opioid crisis, and how libraries are partnering with organizations to meet local needs. This Call to Action is the culminating output for this project and provides five categories of action items to generate ideas and options for how public libraries can engage in opioid response activities. The research also has resulted in a summary report and eight research-based case studies highlighting varying opioid response efforts across the US. Additional information about the project can be found online at oc.lc/opioid-crisis.